header image

Eberly 2018

2018 Eberly Distinguished Lectureship in Immunology

The Eberly Distinguished Lectureship in Immunology was established in 2011 by the Department of Immunology and the Thomas E. Starzl Transplantation Institute to recognize the generous support of the Robert E. Eberly Family and to showcase each year the research of three prominent international leaders in the field of immunology.
Arlene Sharpe, MD, PhD 
George Fabyan Professor of Comparative Pathology
Interim Co-Chair, Microbiology and Immunobiology
Harvard Medical School
"Multifaceted Functions of the PD-1 Pathway"
Thursday, March 22, 2018
Scaife Hall Lecture Room 6


Dr. Arlene Sharpe earned her AB from Harvard University and her MD and PhD degrees from Harvard Medical School. After completing residency training in Pathology at Brigham and Women’s Hospital, she joined the Harvard faculty in 1991. Dr. Sharpe is the George Fabyan Professor of Comparative Pathology, Head of the Division of Immunology, and Interim Co-Chair of the Department of Microbiology and Immunobiology at Harvard Medical School. She is also an Associate Member at the Broad Institute of MIT and Harvard, Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center, and Co-Director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital.

Dr. Sharpe is an international leader in the field of T cell costimulation. Her laboratory has discovered T cell costimulatory and coinhibitory pathways and helped elucidate the functions of B7-1 and B7-2, CTLA-4, ICOS, PD-1 and PD-1 ligands. Her laboratory uses genetic approaches to determine the functions of T cell costimulatory pathways through the generation and analyses of transgenic and knockout mice in mouse models of autoimmunity, infectious diseases, and tumor immunity. In addition, Dr. Sharpe is involved in studies aimed at translating fundamental understanding of T cell costimulation into new therapies for autoimmune diseases, chronic viral infections, and cancer. Current areas of interest in her lab include defining roles of coinhibitory pathways in regulating the induction and maintenance of T cell tolerance and effective antimicrobial and antitumor immunity.

Dr. Sharpe has received multiple honors and held important leadership positions within the scientific community. She was elected President of the American Association of Immunologists in 2016. She is also recipient of a prestigious NIH Merit Award from NIAID.  Thomas Reuters listed Dr. Sharpe as one of the most Highly Cited Researchers (top 1%) in 2014, 2015, and 2017 and a Citation Laureate in 2016. She received the William B. Coley Award for Distinguished Research in Tumor Immunology in 2014 and, in 2017, Dr. Sharpe was recipient of the Warren Alpert Foundation Prize for her contributions to our understanding of the PD-1 pathway.