The Thomas E. Starzl Transplantation Institute has a sustained a diverse leadership in publishing studies with significant findings as well as provocative and field-changing opinions. This page lists a selection of publications from the Institute with impact factor higher than 10 and/or more than 100 citations in the last 5 years.
Impactful Publications
Louis K., Metes DM. Adaptive immune cell responses as therapeutic targets in antibody-mediated organ rejection. Trends in Molecular Medicine. Invited opinion review.2022. 28(3):237-250.
Louis K., Fadakar P., Macedo C., Yamada M., Gu X., Zeevi A., Randhawa P., Lefaucheur C, Metes D. Concomitant loss of regulatory T and B cells is a distinguishing immune feature of antibody-mediated rejection in kidney transplantation. Kidney International. 2022 101(5):1003-1016.
Morelli AE, and Sadovsky Y. Extracellular vesicles and immune response during pregnancy: A balancing act. Immunol. Rev. 2022, 308:105-122.
Bandyopadhyay M, Morelli AE, Balmert SC, Ward NL, Erdos G, Sumpter TL, Korkmaz E, Kaplan DH, Oberbarnscheidt MH, Tkacheva O, Shufesky WJ, Falo LD Jr, Larregina AT. Skin codelivery of contact sensitizers and neurokinin-1 receptor antagonists integrated in microneedle arrays suppresses allergic contact dermatitis. 2022. J Allergy Clin Immunol. doi: 10.1016/j.jaci.2021.12.794. Epub ahead of print.
Dwyer GK, D’Cruz LM, Turnquist HR. Emerging functions of IL-33 in homeostasis and immunity. 2022. Annu Rev Immunol doi: 10.1146/annurev-immunol-101320-124243. Epub ahead of print.
Abou-Daya KI, Oberbarnscheidt MH. Innate allorecognition in transplantation. 2021. J Heart Lung Transplant. 40(7): 557-561. doi: 10.1016/j.healun.2021.03.018. Epub 2021 Mar 29.
Abou-Daya KI, Tieu R, Zhao D, Rammal R, Sacirbegovic F, Williams AL, Shlomchik WD, Oberbarnscheidt MH*, Lakkis FG. Resident memory T cells form during persistent antigen exposure leading to allograft rejection. 2021. Sci Immunol. 6(57). doi: 10.1126/sciimmunol.abc8122. *Co-senior author.
Borelli MA, Li T, Turnquist HR, Little S. Biologics and their delivery systems: Trends in myocardial infarction. 2021. Adv. Drug Deliv. Rev. 173: 181-215.
Cherukuri A, Salama AD, Mehta R, Mohib K, Zheng L, Magee C, Harbar M, Stauss H, Baker RJ, Tevar A, Landsittel D, Lakkis FG, Hariharan S, and Rothstein DM. Transitional B cell cytokines as a predictive biomarker in renal transplantation. Science Translational Medicine 2021. 13(582):eabe4929.
Lin FP, Visina JM, Bloomer PM, Dunn MA, Josbeno DA, Zhang X, Clemente-Sanchez A, Tevar AD, Hughes CB, Jakicic JM, Duarte-Rojo A. Prehabilitation-driven changes in frailty metrics predict mortality in patients with advanced liver disease. Am J Gastroenterol. 2021 Jul 27;. doi: 10.14309/ajg.0000000000001376. [Epub ahead of print] PubMed PMID: 34313620.
Wu D, Poholek CH, Majumder S, Liu Q, Revu SK, Mohib K, Rothstein DM, McGeachy MJ.
IL-17-dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10-producing B cells. Sci Immunol. 2021. 6(66): eaao3669. doi: 10.1126/sciimmunol.aao3669.
Cherukuri A, Mohib K, and Rothstein, DM. Regulatory B cells: TIM-1, transplant tolerance, and rejection. Immunological Reviews. 2021. 299:31-44. doi: 10.1111/imr.12933.
Zeng F, Chen Z, Chen R, Shufesky WJ, Bandyopadhyay M, Camirand G, Oberbarnscheidt MH, Sullivan MLG, Baty CJ, Yang MQ, Calderon M, Stolz DB, Erdos G, Pelanda R, Brennan TV, Catz SD, Watkins SC, Larregina AT, Morelli AE. Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation. 2021. Sci Transl Med. 13(585). doi: 10.1126/scitranslmed.abb0122.
Vats R, Brzoska T, Bennewitz MF, Jimenez MA, Pradhan-Sundd T, Tutuncuoglu E, Jonassaint J, Gutierrez E, Watkins SC, Shiva S, Scott M, Morelli AE, Neal MD, Kato GJ, Gladwin MT, Sundd P. Platelet Extracellular Vesicles Drive Inflammasome-IL1β-dependent Lung Injury in Sickle Cell Disease. Am J Respir Crit Care Med. 2020; 201:33-46.
Shi L, Sun Z, Su W, Xu F, Zhang Q, Dai X, Xie D, Lyer K, Hitchens K, Foley LM, Stolz DB, Chen K, Thomson AW, Chen J and Hu X. (2021) Regulatory T cell-microglia crosstalk promotes white matter repair after ischemic stroke. Immunity. 54:1527-1542.
Abdelsamed HA, Nguyen H*, Zebley C*, Rutishauser RL, Fan Y, Ghoneim H, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw A, McGargill M, Jin H, Boi S, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James E, Nepom GT, Youngblood B. Human self-reactive CD8 T cells acquire stem-cell memory-associated epigenetic programs during development of type 1 diabetes. Nat Immunol. May 2020; 21(5):578-587 (Equal contribution).
Chen L, Sun R, Xu J, Zhai W, Zhang D, Yang M, Yue C, Chen Y, Li S, Turnquist HR, Jiang J, Lu B. Tumor-derived IL33 promotes tissue-resident CD8+ T cells and is required for checkpoint blockade tumor immunotherapy. 2020. Cancer Immunology Research 8: 1381-1392.
Dai H, Lan P, Zhao D, Abou-Daya K, Liu W, Chen W, Friday AJ, Williams A, Sun T, Chen J, Chen W, Mortin-Toth S, Danska JS, Wiebe C, Nickerson P, Li T, Mathews LR, Turnquist HR, Nicotra ML, Gingras S, Takayama E, Kubagawa H, Shlomchik MJ, Oberbarnscheidt MH, Li XC, Lakkis FG. PIRs mediate innate myeloid cell memory to non-self MHC molecules. 2020. Science 368(6495): 1122-1127.
Fisher JD, Zhang W, Balmert SC, Aral AM, Acharya AP, Kulahci Y, Li J, Turnquist HR, Thomson AW, Solari MG, Gorantla VS, Little SR. In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation. 2020. Science Advances 13:6(11): eaax8429.
Hughes AD, Zhao D, Dai H, Abou-Daya KI, Tieu R, Rammal R, Williams AL, Landsittel DP, Shlomchik WD, Morelli AE, Oberbarnscheidt MH*, Lakkis FG. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. 2020. J Clin Invest. 130(1): 287–94. *Co-senior author.
Li T, Zhang Z, Bartolacci JG, Dwyer GK, Liu Q, Mathews L, Velayutham M, Roessing A, Lee YC, Dai H, Shiva S, Oberbarnscheidt MH, Dziki JL, Mullett SJ, Wendell SG, Wilkinson JD, Webber SA, Wood-Trageser MA, Watkins SC, Demetris, AJ, Hussey GS, Badylak SF, Turnquist HR. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. 2020. Journal of Clinical Investigation 130(10): 5397-5412.
Louis K, Macedo C, Bailly E, Lau L, Ramaswami B, Marrari M, Landsittel D, Chang A, Chandran U, Fadakar P, Yamada M, Chalasani G, Randhawa P, Zeevi A, Singh H, Lefaucheur C, and Metes D. Coordinated circulating T follicular helper and activated B cell responses underlie the onset of antibody-mediated rejection in kidney transplantation. J Am Soc Nephrol. 2020 Oct; 31 (10): 2457-2474; PMID: 32723838.
Zhou M, Sacirbegovic F, Zhao K, Rosenberger S, Shlomchik WD. 2020. T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect. Nat Commun 11: 4227.
Cherukuri A, Mehta R, Sharma A, Sood P, Zeevi A, Tevar AD, Rothstein, DM* and Hariharan S*. Post-transplant donor specific antibody is associated with poor kidney transplant outcomes only when combined with both T cell mediated rejection and non-adherence. Kidney Int. 2019. 96:202-21. *equal contribution.
Zamora AE, Crawford JC, Allen EK, Guo XJ, Bakke J, Carter RA, Abdelsamed HA, Moustaki A, Li Y, Chang TC, Awad W, Dallas MH, Mullighan CG, Downing JR, Geiger TL, Chen T, Green DR, Youngblood BA, Zhang J, Thomas PG. Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses. Sci Transl Med. 2019 June;11(498). pii: eaat8549. doi: 10.1126/scitranslmed.aat 8549. PMID: 31243155
Mamcarz E, Zhou S, Lockey T, Abdelsamed HA, Cross SJ, Kang G, Ma Z, Condori J, Dowdy J, Triplett B, Li C, Maron G, Aldave Becerra JC, Church JA, Dokmeci E, Love JT, da Matta Ain AC, van der Watt H, Tang X, Janssen W, Ryu BY, De Ravin SS, Weiss MJ, Youngblood B, Long-Boyle JR, Gottschalk S, Meagher MM, Malech HL, Puck JM, Cowan MJ, Sorrentino BP. Lentiviral gene therapy combined with low-dose Busulfan in Infants with SCID-X1. New England J Med. 2019 April ;380(16):1525-1534. PMID: 30995372
Fisher JD, Zhang W, Balmert SC, Schweizer R, Schnider J, Komatsu K, Dong L, Erbas V, Unadkat JV, Aral AM, Acharya AP, Kulahci Y, Turnquist HR, Thomson AW, Solari M, Gorantla VS, Little SR. Treg-inducing microparticles promote donor-specific tolerance in experimental vascularized composite allotransplantation. 2019. PNAS 116(51): 25784-25789.
Gander JC, Zhang X, Ross K, Wilk AS, McPherson L, Browne T, Pastan SO, Walker E, Wang Z, Patzer RE. Association between dialysis facility ownership and access to kidney transplantation.JAMA. 2019 Sep 10;322(10):957-973. doi: 10.1001/jama.2019.12803. PubMed PMID: 31503308; PubMed Central PMCID: PMC6737748.
Nakao T, Ono Y, Dai H, Nakano R, Perez-Gutierrez A, Camirand G, Huang H, Geller DA and Thomson AW. (2019) DAP12/TREM2 expression by mouse and human liver DC: functional implications and regulation of liver ischemia-reperfusion injury. Hepatology. 70:696-710.
Hughes AD, Lakkis FG, Oberbarnscheidt MH. Four-dimensional imaging of T cells in kidney transplant rejection. 2018. J Am Soc Nephrol 29(6): 1596–600.
Yang MQ, Du Q, Goswami J, Varley PR, Chen B, Wang RH, Morelli AE, Stolz DB, Billiar TR, Li J, Geller DA. Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury. Hepatology. 2018, 67:1056-1070.
Taylor A, Rothstein DM, and Rudd, CE. Small molecule drug inhibition of PD-1 transcription is an effective alternative to antibody blockade in cancer therapy. Cancer Res. 2018. 78:706-717.
Ono Y, Perez-Gutierrez A, Nakao T, Dai H, Camirand G, Yoshida O, Yokota S, Stolz DB, Ross MA, Morelli AE, Geller DA, Thomson AW. Graft-infiltrating PD-L1hi cross-dressed dendritic cells regulate anti-donor T cell responses in mouse liver transplant tolerance. Hepatology. 2018, 67:1499-1515.
Zeng F, Morelli AE. Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer. Semin Immunopathol. 2018, 40:477-490.
Zhang X, Liu YC. The resurgence of scarlet fever in China. Lancet Infect Dis. 2018 Aug;18(8):823-824. doi: 10.1016/S1473-3099(18)30275-5. Epub 2018 May 29. PubMed PMID: 29858151.
Yazdani HO, Chen HW, Tohme S, Tai S, van der Windt DJ, Loughran P, Rosborough BR, Sud V, Beer-Stolz D, Turnquist HR, Tsung A, Huang H. IL-33 exacerbates liver sterile inflammation by amplifying neutrophil extracelluar trap formation. 2018. Journal of Hepatology 68: 130-139.
Ono Y, Perez-Gutierrez A, Nakao T, Dai H, Yoshida O, Yokota S, Beer-Stolz D, Ross MA, Camirand G, Morelli AE, Geller DA and Thomson AW. (2018) Graft-infiltrating PD-L1hi cross-dressed dendritic cells regulate anti-donor T cell responses in liver transplant tolerance. Hepatology. 67:1499-1515, with dedicated Editorial.
Wang L, Zhou Y, Yin J, Gan Y, Wang X, Wen D, Thomson AW, Hu X, Yang L, Stetler A, Li P and Yu W. (2018) Cancer exacerbates ischemic brain injury via Nrp1-mediated accumulation of Treg within the tumor. Stroke. 49:2733-2742.
Hu X, Leak RK, Thomson AW, Yu F, Xia Y, Wechsler LR and Chen J. (2018) Promises and limitations of immune cell-based therapies in neurological disorders. Nature Reviews Neurology. 14:559-568.
Dai H, Watson AR, Fantus D, Peng L, Thomson AW* and Rogers NM. (2018) Rictor deficiency in dendritic cells exacerbates acute kidney injury. Kidney International. 94:951-963. (*AWT and NMR are co-senior authors).
Zheng W, O’Hear CE, Alli R, Basham JH, Abdelsamed HA, Palmer LE, Jones LL, Youngblood B, Geiger TL. PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells. Leukemia 2018 May;32(5):1157-1167. PMID: 29479065
Nakao T, Ono Y, Dai H, Nakano R, Perez-Gutierrez A, Camirand G, Huang H, Geller DA, Thomson AW. DNAX Activating Protein of 12 kDa/Triggering Receptor Expressed on Myeloid Cells 2 Expression by Mouse and Human Liver Dendritic Cells: Functional Implications and Regulation of Liver Ischemia-Reperfusion Injury. Hepatology. 2018 Oct 29. doi: 10.1002/hep.30334. [Epub ahead of print]
Cherukuri A, Salama AD, Carter CR, Davison A, Hernandez-Fuentes M, Hewitt E, Clark B, Rothstein, DM,* and Baker R*. Human transitional B cell T1/T2 ratio is a new marker for allograft deterioration in kidney transplant recipients. Kidney Int. 2017. 91:183-195. *denotes equal contribution. (Article is accompanied by an Editorial).
Dai H, Friday AJ, Abou-Daya KI, Williams AL, Mortin-Toth S, Nicotra ML, Rothstein DM, Shlomchik WD, Matozaki T, Isenberg JS, Oberbarnscheidt MH, Danska JS and Lakkis FG. Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts. 2017. Science Immunology 2(12).
Wiede F, Sacirbegovic F, Leong YA, Yu D, Tiganis T. 2017. PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity. J Autoimmun 76: 85-100.
Xu J, Guardado J, Hoffman R, Xu H, Namas R, Vodovotz Y, Xu L, Ramadan M, Brown J, *Turnquist HR, *Billiar TR. IL-33 mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model. 2017. PLoS Medicine 14(7): e1002365. *Co-Senior and *Corresponding Author.
Abdelsamed HA, Moustaki A, Fan Y, Dogra P, Ghoneim HE, Zebley CC, Triplett BM, Sekaly RP, Youngblood B. Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis. J Exp Med. 2017 June;214(6):1593-1606. PMID: 28490440
Ghoneim HE, Fan Y, Moustaki A, Abdelsamed HA, Dash P, Dogra P, Carter R, Awad W, Neale G, Thomas PG, Youngblood B. De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation. Cell. 2017 June;170(1):142-157. PMID: 28648661
Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, Haining WN, McElrath MJ, Zhang D, Hu B, Greenleaf WJ, Goronzy JJ, Mulligan MJ, Hellerstein M, Ahmed R. Origin and differentiation of human memory CD8 T cells after vaccination. Nature. 2017 Dec; 552(7685):362-367. PMID: 29236685
Boyette LB, Macedo C, Hadi K, Elinoff BD, Walters JT, Ramaswami B, Chalasani G, Taboas JM, Lakkis FG, Metes DM. Phenotype, function, and differentiation potential of human monocyte subsets. Plos One. 2017 Apr; 12 (4): e0176460 PMID: 28445506.
Ono Y, Perez-Gutierrez A, Nakao T, Dai H, Camirand G, Yoshida O, Yokota S, Stolz DB, Ross MA, Morelli AE, Geller DA, Thomson AW. Graft-infiltrating PD-L1hi cross-dressed dendritic cells regulate anti-donor T cell responses in mouse liver transplant tolerance. Hepatology. 2017 Sep 16. doi: 10.1002/hep.29529. [Epub ahead of print]
Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HHW, Shapiro S, Zhao Y, Goncharova EA: HIPPO-integrin linked kinase crosstalk controls self-sustaining proliferation and survival in pulmonary hypertension. Am J Respir Crit Care Med. 2016, 194:866-877.
Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Beer Stolz D, Erdos G, Sullivan MLG, Gibson GA, Watkins SC, Larregina AT, and Morelli AE. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016, 126:2805-2820.
Alegre ML, Lakkis FG, and Morelli AE. Antigen presentation in transplantation. Trends Immunol. 2016, 37:831-843.
Liew FY, Girard J-P, Turnquist HR. Interleukin-33 in health and disease. 2016. Nature Reviews Immunology 16: 676-689.
Matta BM, Reichenbach DK, Zhang X, Mathews L, Koehn BH, Dwyer GK, Lott JM, Uhl FM, Pfeifer D, Feser CJ, Smith MF, Liu Q, Zeiser R, Blazar BR, Turnquist HR. Peri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GVHD. 2016. Blood 128(3): 427-439.
Zhuang Q, Liu Q, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH*, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. 2016. Nat Commun 7: 12623. *Co-senior author
Yatim KM, Gosto M, Humar R, Williams AL, Oberbarnscheidt MH. Renal dendritic cells sample blood-borne antigen and guide T-cell migration to the kidney by means of intravascular processes. 2016. Kidney Int. 90(4): 818-27.
Zhang X, Hou F, Li X, Zhou L, Liu Y, Zhang T. Study of surveillance data for class B notifiable disease in China from 2005 to 2014. Int J Infect Dis. 2016 Jul;48:7-13. doi: 10.1016/j.ijid.2016.04.010. Epub 2016 Apr 14. PubMed PMID: 27094249; PubMed Central PMCID: PMC7110548.
Rogers NM, Zhang ZJ, Wang J-J, Thomson AW and Isenberg JS. (2016) CD47 regulates renal tubular cell self-renewal and proliferation following renal ischemia reperfusion. Kidney International. 90:334-337.
Yokota S, Ueki S, Ono Y, Kasahara N, Pérez-Gutiérrez A, Yasuda Y, Kimura S, Yoshida O, Murase N, Geller DA and Thomson AW. (2016) Orthotopic mouse liver transplantation to study liver immunobiology and allograft tolerance. Nature Protocols. 11:1163-1174.
Fantus D, Rogers NM, Grahammer F, Huber TB and Thomson AW. (2016) Roles of mTOR complexes in the kidney: implications for renal disease and transplantation. Nat Rev Nephrol. 12:587-609.
Sumpter TL, Ho CH, Pleet AR, Tkacheva OA, Shufesky WJ, Rojas-Canales DM, Morelli AE, and Larregina AT. Signalling mast cells via the neurokinin-1 receptor by autocrine agonists is necessary for development and progression of anaphylaxis and atopic asthma. J Allergy Clin Immunol. 2015, 135:1019-1030.
Karadge UG, Gosto M, Nicotra ML. Allorecognition proteins in an invertebrate exhibit homophilic interactions. Current Biology. 2015;25(21): 2845-850. Pubmed PMID: 26455308.
Roedder S, Li L., Alonso M, Hsieh SC, Vu MT, Dai H, Sigdel TK, Bostock I, Macedo C, Metes D, Zeevi A, Shapiro R, Salvatierra O, Scandling J, Alberu J, Engleman E, Sarwal MM. A three-gene assay for monitoring immune quiescence in kidney transplantation. J Am Soc Nephrol. 2015 Aug; 26(8):2042-53; PMID 25429124.
Cherukuri A, Rothstein, DM, Salama AD, Carter CR, Davison A, Hernandez-Fuentes M, Hewitt E, Clark B, and Baker R. Immune regulation by human B cell subsets is influenced by the balance of IL-10 and TNF-a secretion. J Am Soc Nephrol. 2014. 25:1575-85.
Oberbarnscheidt MH, Zeng Q, Li Q, Dai H, Williams AL, Shlomchik WD, Rothstein DM, Lakkis FG. Non-self recognition by monocytes initiates allograft rejection. J Clin Invest. 2014. 124:3579-89.
Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM. CD45 ligation expands Tregs by promoting interactions with DCs. J. Clin. Invest. 2014; 124:4603-4613.
Camirand G, Wang Y., Wan YY, Kai YJ., Guz, G., Deng S., Farber, D., Perkins, DL., Finn, PW., Flavell RA., Lakkis, FG, Shlomchik, WD, and Rothstein, DM. CD45 ligation expands Tregs by promoting interactions with dendritic cells. J Clin Invest. 2014. 124:4603-13. (Featured in Research Highlights: Nature Reviews Immunology 2014. 14:648.
Robbins PD and Morelli AE. Regulation of the immune response by extracellular vesicles. Nature Rev Immunol. 2014, 14:195-208.
Zhang X, Zhang T, Young AA, Li X. Applications and comparisons of four time series models in epidemiological surveillance data. PLoS One. 2014;9(2):e88075. doi: 10.1371/journal.pone.0088075. eCollection 2014. PubMed PMID: 24505382; PubMed Central PMCID: PMC3914930.
Yao M, Rogers NM, Csanyi G, Rodriguez AI, Ross MA, St. Croix C, Knupp H, Novelli EM, Thomson AW, Pagano PJ and Isenberg JS. (2014) Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury. JASN. 25:1171-86.
Castellaneta A, Yoshida O, Kimura S, Yokota S, Geller DA, Murase N and Thomson AW. (2014) Plasmacytoid dendritic cell-derived IFN-α promotes murine liver ischemia/reperfusion injury by induction of hepatocyte IRF-1. Hepatology. 60:267-277.
Li P, Mao L, Liu X, Gan Y, Zheng J, Thomson AW, Gao Y, Chen J and Hu X. (2014) Essential role of program death 1-ligand 1 in regulatory T cell-afforded protection against blood-brain barrier damage after stroke. Stroke. 45:857-864.
Rogers NM, Ferenbach DA, Isenberg JS, Thomson AW* and Hughes J*. (AWT and JH are *co-senior authors) (2014) Dendritic cells and macrophages in the kidney: a spectrum of good and evil. Nature Reviews Nephrology. 10:625-643.
Roedder S, Sigdel T, Salomonis N, Hsieh S, Dai H, Bestard O, Metes D, Zeevi A, Gritsch A, Cheeseman J, Macedo C, Peddy R, Medeiros M, Vincenti F, Asher N, Salvatierra O, Shapiro R, Salvatierra O, Kirk A, Reed E, Sarwal M M. The kSORT assay to detect renal transplant patients at high risk for acute rejection: Results of the Multicenter AART Study PLoS Med. 2014 Nov; 11(11): e1001759; PMID 25386950
Zeng Q, Ng YH, Singh T, Jiang K, Sheriff KA, Ippolito R, Zahalka Z, Li Q, Randhawa P, Hoffman R, Ramaswami B, Lund F, Chalasani G. B cells mediate chronic allograft rejection independently of antibody production. J Clin Invest. 2014; 124(3):1052–1056. doi:10.1172/JCI70084 (**cited in F1000Prime; F1000Prime.com/718270623#eval793492446)
Janelsins BM, Sumpter TL, Tkacheva OA, Rojas-Canales DM, Erdos G, Mathers A, Shufesky WJ, Storkus WJ, Falo LD, Morelli AE, and Larregina AT. Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type-1 immunity by licensing host dendritic cells to produce IL-12. Blood. 2013, 121:2923-2933.
Delorme-Axford E, Donker RB, Mouillet J-F, Chu T, Bayer A, Ouyang Y, Wang T, Beer Stolz D, Sarkar SR, Morelli AE, Sadovsky Y, and Coyne CB. Human placental trophoblasts confer viral resistance to recipient cells. Proc Nat Acad Sci USA. 2013, 110:12048-12053.
Walch JM, Zeng Q, Li Q, Oberbarnscheidt MH, Hoffman RA, Williams AL, Rothstein DM, Shlomchik WD, Kim JV, Camirand G, Lakkis FG. Cognate antigen directs CD8+ T cell migration to vascularized organ transplants. J Clin Invest. 2013. 123:2663.
Zhang M, Ueki S, Yoshida O, Castellaneta A, Ozaki KS, Kimura S, Vodovotz Y, Thomson AW, Beer-Stolz D, Geller DA and Murase N. (2013) Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury. Hepatology. 57;1585-1596.
Li P, Gan Y, Sun B-L, Zhang F, Lu B, Gao Y, Liang W, Thomson AW, Chen J and Hu X. (2013) Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann Neurol. 74:458-471.
Rosborough BR, Raïch-Regué D, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M, Turnquist HR, and Thomson AW. (2013) Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction. Blood. 121:3619-3630.
Yoshida O, Kimura S, Jackson E, Robson SC, Geller DA, Murase N, and Thomson AW. (2013) CD39 expression by hepatic myeloid dendritic cells attenuates their pro-inflammatory activity and liver transplant ischemia-reperfusion injury. Hepatology. 58:2163-75.
Schneeberger S, Gorantla VS, Brandacher G, Zeevi A, Demetris AJ, Lunz III J, Metes D, Donnenberg AD, Shores JT, Dimartini AF, Kiss JE, Imbriglia JE, Azari K, Goitz RJ, Manders EK, Nguyen VT, Cooney DS, Wachtman GS, Keith JD, Fletcher DR, Macedo C, Losee JE, Shapiro R, Starzl TE, Lee WPA. Upper-Extremity transplantation using a cell-based protocol to minimize immunosuppression. Ann Surg. 2013 Feb; 257(2):345-51; PMID 23001085
Montecalvo A, Larregina AT, Shufesky WJ, Beer Stolz D, Sullivan MLG, Karlsson JM, Baty CJ, Gibson GA, Erdos G, Wang Z, Milosevic J, Tkacheva OA, Divito SJ, Jordan R, Lyons-Weiler J, Watkins SC, and Morelli AE. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012, 119:756-766.
Donker RB, Mouillet J-F, Chu T, Hubel CA, Beer Stolz D, Morelli AE, and Sadovsky Y. The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes. Mol Hum Reprod. 2012, 18:417-424.
Jhunjhunwala S, Balmert S, Raimondi G, Dons E, Nichols E, Thomson AW, and Little SR. (2012) Controlled release formulations of IL-2, TGF-β and rapamycin for the induction of regulatory T cells. J Controlled Release. 159:78-84.
Jhunjhunwala S, Raimondi G, Glowacki AJ, Hall SJ, Maskarinec D, Thorne SH, Thomson AW, Little SR. (2012) Bio-inspired controlled release of CCL22 recruits regulatory T cells in vivo. Adv Mater. 24:4735-4738.
Hermann BP, Sukhwani M, Winkler F, Pascarella JN, Peters, KA, Sheng Y, Valli H, Rodriguez M, Ezzelarab M, Dargo G, Peterson K, Masterson K, Ramsey C, Ward T, Lienesch M, Volk A, Cooper DK, Thomson AW, Kiss JE, Penedo C, Schatten GP, Mitalipov S and Orwig KE. (2012) Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm. Cell Stem Cell. 11:715-726.
Stenger EO, Turnquist HR, Mapara MY, and Thomson AW. (2012) Dendritic cells and regulation of graft-versus-host and graft-versus-leukemia activities. Blood. 119;5088-5103.
Rogers NM, Thomson AW, and Isenberg JS. (2012) Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury. JASN. 23:1538-1550.
Stefanovic-Racic M, Yang X, Turner MS, Mantell BS, Stolz DB, Sumpter TL, Sipula IJ, Dedousis N, Scott DK, Morel PA, Thomson AW and O’Doherty RM. (2012) Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver. Diabetes. 61:2330-2339.
Ding Q, Yueng M, Camirand G, Zeng Q, Akiba H, Yagita H, Chalasani G, Sayegh MH, Najafian N, and Rothstein DM. Regulatory B cells are identified by TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest. 2011. 121:3645-56.
Houser BL, Tilburgs T, Hill J, Nicotra ML, Strominger JL. “Two unique human decidual macrophage populations.” Journal of Immunology. 2011;186(4):2633-2642. Pubmed PMID: 21257965.
Ueki S, Castellaneta A, Yoshida O, Ozaki K, Zhang M, Kimura S, Isse K, Ross M, Shao L, Stolz DB, Thomson AW, Demetris AJ, Geller DA and Murase N. (2011) Hepatic B7-H1 expression is essential for controlling cold ischemia/reperfusion injury after mouse liver transplantation. Hepatology 54:216-228.
Turnquist HR, Zhoa Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, Wang Z, Lang M, Beer-Stolz D, Zheng X-X, Demetris AJ, Liew FY, Wood KJ, and Thomson AW. (2011) IL-33 expands suppressive CD11b+ Gr-1int and regulatory T cells, including ST2L+ Foxp3+ cells and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol. 187:4598-4610. Featured as top 10% article.
Ezzelarab M and Thomson AW. (2011) Tolerogenic dendritic cells and their role in transplantation. Seminars in Immunology. 23:252-263.
Divito SJ, Montecalvo A, Wang Z, Shufesky WJ, Erdos G, Larregina AT, and Morelli AE. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 2010, 116:2694-2705.
Rosa SFP, Powell AE, Rosengarten RD, Nicotra ML, Moreno MA, Grimwood J, Lakkis FG, Dellaporta SL, Buss LW. “Hydractinia allodeterminant alr1 resides in an Immunoglobulin Superfamily-like gene complex.” Current Biology. 2010;20(12):1122-1127. Pubmed PMID: 20537535.
Rosengarten RD and Nicotra ML. “Model systems of invertebrate allorecognition.” Current Biology. 2010;21(2):R82-92. Pubmed PMID: 21256442.
Skuk D, Paradis M, Goulet M, Chapdelaine P. Rothstein DM, and Tremblay JP. Intramuscular transplantation of human postnatal myoblasts generates functional donor-derived satellite cells. Mol Ther. 2010. 18:1689-97.
Turnquist HR, Cardinal J, Macedo C, Rosborough BR, Sumpter TL, Geller DA, Metes D, and Thomson AW. (2010) mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS. Blood. 115(23):4758-69.
Thomson AW and Knolle PA. (2010) Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol. 10:753-766.
Matta BM, Castellaneta A and Thomson AW. (2010) Tolerogenic plasmacytoid DC. Eur J Immunol. 40:2667-76.
Hilkens CVU, Isaacs JD and Thomson AW. (2010) Development of dendritic cell-based immunotherapy for autoimmunity. Int Rev Immunol. 29:156-183.
Janelsins BM, Mathers AR, Tkacheva OA, Shufesky WJ, Morelli AE, and Larregina AT. Pro-inflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity. Blood. 2009, 113:3017-3026.
Li C, Houser BL, Nicotra ML, Strominger JL. “HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells.” Proceedings of the National Academy of Sciences of the United States of America. 2009;106(14):5767-5772. Pubmed PMID: 19304799.
Nicotra ML, Powell AE, Rosengarten RD, Moreno MA, Grimwood J, Lakkis FG, Dellaporta SL, Buss LW. “A hypervariable invertebrate allodeterminant.” Current Biology. 2009;19(7):583-589. Pubmed PMID: 19303297.
Li X, Rothstein DM and Sayegh MH. Costimulatory pathways in transplantation: challenges and new developments. Immunol. Rev. 2009. 229:271-93.
Tremblay JP, Skuk D, Palmieri B, and Rothstein DM. A case for immunosuppression for myoblast transplantation in Duchenne Muscular Dystrophy. Mol. Ther. 2009. 17:1122-42.
Jhunjhunwala S, Raimondi G, Thomson AW and Little SR. (2009) Delivery of rapamycin to dendritic cells using degradable microparticles. J Controlled Release. 133:191-197.
Lau AH, Szabo G and Thomson AW. (2009) Antigen-presenting cells under the influence of alcohol. Trends in Immunology. 30;13-22. FEATURED COVER ARTICLE.
Thomson AW, Turnquist HR and Raimondi G (2009). Immunoregulatory effects of mTOR inhibition. Nature Reviews Immunology. 9:324-337.
Zeng G, Bueno M, Camachos CJ, Ramaswami B, Luo C, Randhawa P. Validation of BKV large T-antigen ATP-binding site as a target for drug discovery. Antiviral Res. 2009; 81(2): 184 – 187.
Kettleson EM, Ramaswami B, Hogan CJ, Lee MH, Statyukha GA, Biswas P, and Angenent LT. Airborne virus capture and inactivation n by an electrostatic particle collector. Environmental Science and Technology. 2009; 43(15): 5940 – 5946.
Li C, Ge B, Nicotra ML, Stern J, Kopcow H, Chen X, Strominger JL. “JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity.” Proceedings of the National Academy of Sciences of the United States of America. 2008;105(8):3017- 3022. Pubmed PMID: 18287025.
Montecalvo A, Shufesky WJ, Beer Stolz D, Sullivan MG, Wang Z, Divito S, Papworth GD, Watkins SC, Robbins PD, Larregina AT, and Morelli AE. Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T-cell allorecognition. J Immunol. 2008, 180:3081-3090.
Ueno, T, Habicht, A, Albin, M, Wang, Y., Clarkson, M, Yagita, H, Akiba, H, Rothstein, DM, Najafian, N and Sayegh, M. The emerging role of T cell immunoglobulin mucin 1 (Tim-1) In alloimmune responses in vivo. J Clin Invest. 2008. 118:742-51.
Li W, Kuhr CS, Liang Y, Carper K, Zheng XX, Perkins DL, Reyes JD, Thomson AW, and Perkins JD. (2008) New insights into the mechanisms of liver transplant tolerance: the role of Foxp3-expressing CD25+ CD4+ regulatory T cells. Am J Transplant. 8:1639-1651.
Tokita A, Mazariegos GV, Zahorchak AF, Chien N, Abe M, Raimondi G and Thomson AW. (2008) High PD-L1/CD86 ratio on plasmacytoid DC correlates with elevated T regulatory cell frequency in operational liver transplant tolerance. Transplantation. 85:369-377.
Tokita D, Sumpter TL, Raimondi G, Zahorchak AF, Wang Z, Nakao A, Mazariegos GV, Abe M and Thomson AW. (2008) Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity and dependent on regulatory T cells. J Hepatology. 49(6):1008-18.
