Fadi G. Lakkis, MD
Frank & Athena Sarris Chair in Transplantation Biology; Professor of Surgery, Immunology and Medicine; Scientific Director, Thomas E. Starzl Transplantation Institute
MD, American University of Beirut, Lebanon
Innate and adaptive mechanisms of allograft rejection
The goal of my research is to understand the fundamental mechanisms of acute and chronic rejection in solid organ transplantation. The principal areas of investigation in my laboratory are the innate mechanisms responsible for initiating and perpetuating the alloimmune response and the role of memory T cells in allograft rejection. Mouse models of skin, heart, kidney, and islet transplantation, as well as an invertebrate allorecognition model, are employed to address these areas of investigation. Intravital multiphoton microscopy is used to investigate the mechanisms of monocyte and memory T cell migration to the transplanted mouse kidney. My lab is also part of a human immunology group investigating innate and adaptive immune function in kidney transplant recipients.